There have been numerous reports that have explored the role of topical aloe vera administration in skin conditions and wound healing management, including the treatment of psoriasis, dermatitis, oral mucositis, surgical wounds and as a home remedy for burn injuries. The first study of this kind was surprisingly done in 1935! Aloe vera extract was reported to provide rapid relief from the itching and burning associated with severe radiation dermatitis and skin regeneration.
A 1996 study done at the Department of Clinical Physiology in Sweden included 60 patients with chronic psoriasis who participated in a randomized, double-blind, controlled trial of aloe vera or placebo cream. The cure rate in the aloe vera group was 83 percent (!) compared to only 7 percent in the placebo group, and there were no relapses reported at the 12-month follow-up.
In 2009, a systematic review summarized 40 studies that involved using aloe vera for dermatological purposes. The results suggest that oral administration of aloe vera in mice works effectively to heal wounds, can decrease the number and size of papillomas (small growths on the skin), and reduce the incidence of tumors by more than 90 percent in the liver, spleen and bone marrow. The studies also showed that aloe vera effectively treats genital herpes, psoriasis, dermatitis, frostbite, burns and inflammation. It can be used safely as an antifungal and antimicrobial agent.